Code & Data
SIFT for in-house use (version 4.0.2, released February 5, 2010)
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Prediction on human SNPs
Literature
Our review "Predicting the Effects of Amino Acid Substitutions on Protein Function" in
Annual Review of Genomics and Human Genetics
Chapter
Supplementary Table 1
Referencing SIFT
Predicting Deleterious Amino Acid Substitutions, Genome Res. 2001 May; 11(5): 863.874.
(Link)
Accounting for Human Polymorphisms Predicted to Affect Protein Function, Genome Res. 2002 December; 436-446
(Link)
SIFT: predicting amino acid changes that affect protein function, Nucleic Acids Research, 2003, Vol. 31, No. 13 3812-3814
(Link)
Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm, Nature Protocols 4, - 1073 - 1081 (2009)
(Link)
SIFT
predicts whether an
amino acid substitution affects protein function
based on sequence homology and the physical properties of amino acids. SIFT can be applied to naturally occurring
nonsynonymous polymorphisms and laboratory-induced missense mutations.
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Genome Tools |
Tool Description/Input |
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Extract coding variants from a large list of genomic variants |
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Provides SIFT predictions for variants with genome coordinates |
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Indel variants in genome coordinates |
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Batch Tools |
Tool Description/Input |
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Multiple proteins identifiers |
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Multiple rsIDs (NCBI dbSNP) |
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Single Protein Tools |
Tool Description/Input |
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Single protein (RefSeq ID /gi number) |
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Single protein (Query sequence) |
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Single protein (Query with related sequences) |
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Single protein (Query with aligned sequences) |
1. Restrict to coding variants
Other prediction tools for amino acid substitutions: PolyPhen , MAPP , SNPs3D